Resident Evil 4: Wii Edition Cheats

Unockable: Mercenaries Mini-Game
Beat the game to unlock the mercenaries mini game.

Unlockable: Punisher Weapon
Shoot 10 of the fifteen blue medallions in the game. There is a map you can find in the farm area just beyond the first village with the bell tower. After collecting the map, the locations of all fifteen medallions will appear on your map. When youve destroyed at least 10, talk to the merchant for a free gun.

Unlockable: Assignment Ada Mini-game
Beat the game to unlock the mini game.

Unlockable: Broken Butterfly Weapon
In the hall south of the hedge maze there is a locked door. Return to that area with Ashley, piggy back with her and she will unlock the door. This reveals the broken butterfly.

Unlockable: Rocket Launcher
In order to unlock the Rocket Launcher Special you beat the game on Normal and you get a chance too buy the Matilda and the Infinite Launcher. The Matilda is $70,000 and the Infinite Launcher is $1000000.

Unlockable: S.T.A.R.S. Uniform
To Unlock The S.T.A.R.S. Uniform You Must Complete The Game On Normal Or Hard Mode.

Unlock Matilda Weapon
Unlock the Matilda handgun (which fires 3 round bursts) by clearing the game.

Unlockable: Hand Cannon Weapon

Unlockable: Thompson (Chicago Typewriter)
Beat Operation Ada, and the “Chicago Typewriter”, a Thompson with 10.0 firepower, infinite ammo, no reload, and the fire rate of a maxed out TMP, becomes available at the merchant.
Beating Operation Ada will only unlock the Chicago Typewriter for Ada in her Separate Ways mission and not any other mode.
To unlock the Thompson for Leons mission you need to beat the Adas Separate Ways mission.